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Jordan
McCallister
45 • Female
5’3”
127lbs
Penicillin
Sulfonamides
Codeine
Gluten
Hashimoto’s
Perioral dermatitis
Overview
Labs + Diagnostics
Genetics
Rx + Supplements
3
Encounters + Notes
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Patient Focus
45 year-old female, preventive and longevity-oriented individual seeking sustained energy, optimized sleep, and thyroid support.
General Overview
Context of Care
Longitudinal care across UCSF/MarinHealth since 2019 with Endocrinology/Dermatology; active problems: acquired hypothyroidism , thyroid nodule, perioral dermatitis , history of hyperparathyroidism with hypocalcemia, benign skin lesions; personal Hashimoto’s, maternal rosacea, grandmother thyroidectomy (reason unknown).
Course/response: flares build over 1–2 weeks and resolve only with antibiotics or reduced thyroid dose; TIROSINT 120→88 mcg briefly cleared for 2–3 weeks; cheek culture normal flora; using ivermectin 1% cream daily; ~90% improved at intake.
Triggers/psychosocial: sunburn, makeup, and red wine worsen flares; tolerates only light moisturizer and prefers natural products; stress has high daily impact and flares are embarrassing; uses meditation and exercise for coping.
Thyroid therapy/trajectory: on TIROSINT (levothyroxine) plus liothyronine; TSH largely suppressed in 2022–2025, then elevated with low‑normal Free T4 in 01/2026 while on TIROSINT 75 mcg daily.
Thyroid/Parathyroid findings: 02/2022 US—heterogeneous thyroid with 0.7 cm TI-RADS 4 right nodule (<1 cm, no follow-up) and 0.6 cm focus possibly parathyroid; 03/2023 US—no discrete thyroid nodules; persistent small oval structure posterior to right thyroid (possible parathyroid adenoma vs lymph node). History of hyperparathyroidism/hypocalcemia with PTH 94 pg/mL (10/2022) and later normal values; calcium intermittently low‑normal (e.g., 8.5 mg/dL in 09/2024).
Sex steroid profile: marked estradiol/testosterone elevations on 10/27/2023 with estradiol decreased 11/2023; on testosterone gel with total testosterone 37 ng/dL (04/03/2025) and 80 ng/dL (01/05/2026).
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hypothyroidism
perioral dermatitis
TIROSINT 120→88 mcg
Ivermectin 1%
Patient History
See All Events
Jan 12, 2026
Infectious disease screening
HIV • Syphilis • HBV • HCV
All non-reactive
Jan 05, 2026
Hormone therapy follow-up
Testosterone gel • Total T 80 ng/dL
Total T 80 ng/dL
Jan, 2026
Thyroid labs - TSH now elevated
TIROSINT 75 mcg • Free T4 low-normal
TSH elevated
Late 2025
Skin cleared with thyroid dose
TIROSINT 120 → 88 mcg • Skin clear 2-3 weeks
Perioral dermantitis
Genetics
Polygenic Risk Score (PGS)
640 traits scored
227 high risk
Highest Risk Categories
Cancer
Cardiovascular Disease
Digestive System Disorder
Genetic Findings
APOE
Pathogenic
HLA
Likely Pathogenic
MTHFR
Likely Pathogenic
Pharmacogenomics (PGX)
Levothyroxine
AB123 • Lorem ipsum
Adjust Dose
Sertraline
AB123 • Lorem ipsum
Monitor
Metformin
AB123 • Lorem ipsum
Avoid
Rx + Supplements
Medications
Levothyroxine
50mcg
Daily
Active
Levothyroxine
50mcg
Daily
Active
Over the counter
Vitamin C
500mg
Daily
Active
Ibuprofen
400mg
As needed
Active
Zyrtec
10mg
Daily
Stopped
Supplements
Vitamin D3
5,000 IU
Daily
Active
Vitamin K2
100 mcg
Daily
Paused
Ferrous Bisglycinate
25 mg
Daily
Active
Magnesium Glycerinate
400 mg
Daily
Inconsistent
Selenium
200 mcg
Daily
Stopped
2,000+ patients synthesized
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Profile replaces the clipboard with a guided intake that captures history, symptoms, and consent in the patient's own words — then hands your staff a completed record instead of a stack to transcribe.
02
We retrieve the record
A lifetime of labs, notes, imaging, and prescriptions pulled across 600,000+ providers through CareQuality and direct EHR integration.
03
Genome meets record
50GB+ of whole-genome data, normalized and scored against the patient's actual genetic ancestry, then read against their clinical history.
04
Ready before the visit
One synthesized view, seamlessly presented. Not a 400-page report—the genetics, the clinical history, and the findings that change what you do next, in a single place.
The reference cohorts that produced the published scores were overwhelmingly European. Applied to anyone else, they lose accuracy quietly — and in the direction of missing risk. Profile resolves genetic ancestry before scoring, so the number means something for the patient it describes.
Preprocessing, ancestry, polygenic risk across 640+ traits, pharmacogenomics on the active medication list, and clinical variants classified against ClinVar, gnomAD, and ClinGen.
Every finding traces back to a curated variant database, a published score, or a line in your patient's own record. Variants of uncertain significance stay labeled uncertain. You can follow any statement on the screen to where it came from.
Profile was designed by people who have to use it—a practicing clinician, a molecular pathologist, and a founder who has spent years being the patient whose diagnosis took too long. It's built for a real visit because it was built inside one.
Dr. Brendan Cochran, CMO
Clinician and founder of Interactive Health Clinic. International lecturer in longevity medicine, chronic disease, integrative oncology.
Dr. Tushar Chakravarty, CSO
Physician and molecular pathologist (UCSF). Built a genomics lab from the ground up at Loma Linda. Biochemistry, Johns Hopkins.
Quinton Poncelet, CAIO
CERN physicist and AI researcher; high-energy physics and advanced simulation, now powering Profile's genotype × phenotype pipeline.
Mandi Bateman, CEO
Repeat founder; scaled products across health and edtech. And the patient—living with autoimmune disease, she sees the problem from the inside.
Genetic intelligence for clinicians. Whole-genome sequencing plus a lifetime of records, synthesized into one view and delivered into your EHR.
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